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Hyaluronic acid explained: HMW vs LMW, and why size matters
Skincare · 5 min read

Hyaluronic acid explained: HMW vs LMW, and why size matters

by Pavel Rozhkov ·

Hyaluronic acid is the most popular skincare ingredient on the planet — and the most misunderstood. Used wrong, it dehydrates the skin it was supposed to plump. Used right, it transforms it.

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Hyaluronic acid (HA) is a humectant — it pulls water in. The catch: it pulls from wherever water is available, including the deeper layers of your own skin if there is no atmospheric moisture to draw from. In dry environments (heated apartments, arid Gulf summers, airplane cabins) applying pure HA without sealing it accelerates dehydration.

Molecular weight (MW) decides depth and feel. High-molecular-weight HA (HMW, >1000 kDa) sits on the surface, forms a film and provides immediate plumping — best for instant glow. Low-molecular-weight HA (LMW, 50–300 kDa) penetrates the upper epidermis, hydrates deeper layers and supports barrier repair over weeks.

The best serums combine three to five molecular weights for a 'multi-MW cascade'. Two non-negotiable application rules: apply HA on damp skin (not dry — it needs water to pull) and lock immediately with an occlusive moisturizer or oil. Skip HA entirely if you live in low-humidity (<30%) without humidifier; use glycerin or polyglutamic acid instead — both are humectants that perform better in dry air.

And lower the concentration: 1% is plenty, 2% on damp skin is luxury, anything above is a marketing number.

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